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Target
Histone deacetylase 1
Ligand
BDBM50024663
Substrate
n/a
Meas. Tech.
ChEMBL_1438101 (CHEMBL3388476)
IC50
21±n/a nM
Citation
 Cheng, J; Qin, J; Guo, S; Qiu, H; Zhong, Y Design, synthesis and evaluation of novel HDAC inhibitors as potential antitumor agents. Bioorg Med Chem Lett 24:4768-72 (2014) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50024663
Synonyms:
CHEMBL3334995
Type:
Small organic molecule
Emp. Form.:
C17H16FN3O3
Mol. Mass.:
329.3256
SMILES:
ONC(=O)c1ccc(cc1)N1CCN(Cc2ccc(F)cc2)C1=O
Structure:
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