Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50024665
Substrate
n/a
Meas. Tech.
ChEMBL_1438101 (CHEMBL3388476)
IC50
12±n/a nM
Citation
 Cheng, J; Qin, J; Guo, S; Qiu, H; Zhong, Y Design, synthesis and evaluation of novel HDAC inhibitors as potential antitumor agents. Bioorg Med Chem Lett 24:4768-72 (2014) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50024665
Synonyms:
CHEMBL3334996
Type:
Small organic molecule
Emp. Form.:
C18H19N3O4
Mol. Mass.:
341.3612
SMILES:
COc1ccc(CN2CCN(C2=O)c2ccc(cc2)C(=O)NO)cc1
Structure:
Search PDB for entries with ligand similarity: