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Target
Histamine H3 receptor
Ligand
BDBM50026354
Substrate
n/a
Meas. Tech.
ChEMBL_1432177 (CHEMBL3390513)
Ki
<100±n/a nM
Citation
 Lipani, L; Odadzic, D; Weizel, L; Schwed, JS; Sadek, B; Stark, H Studies on molecular properties prediction and histamine H3 receptor affinities of novel ligands with uracil-based motifs. Eur J Med Chem 86:578-88 (2014) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50026354
Synonyms:
CHEMBL3331158
Type:
Small organic molecule
Emp. Form.:
C25H39N3O3
Mol. Mass.:
429.5955
SMILES:
C[C@H]1CCCN1CCCOc1ccc(cc1)C(\CN1CCCCC1=O)=N\OC(C)(C)C |r|
Structure:
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