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Target
Thromboxane A2 receptor
Ligand
BDBM50026758
Substrate
n/a
Meas. Tech.
ChEMBL_1437451 (CHEMBL3387261)
IC50
11±n/a nM
Citation
 Wang, X; Liu, L; Huang, L; Herbst-Robinson, K; Cornec, AS; James, MJ; Sugiyama, S; Bassetto, M; Brancale, A; Trojanowski, JQ; Lee, VM; Smith, AB; Brunden, KR; Ballatore, C Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. ACS Med Chem Lett 5:1015-20 (2014) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50026758
Synonyms:
CHEMBL3335473
Type:
Small organic molecule
Emp. Form.:
C18H18ClNO4S
Mol. Mass.:
379.858
SMILES:
OC(=O)Cc1cccc2CC(CCc12)NS(=O)(=O)c1ccc(Cl)cc1
Structure:
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