Reaction Details Report a problem with these data
Target
Gamma-butyrobetaine dioxygenase
Ligand
BDBM50028971
Substrate
n/a
Meas. Tech.
ChEMBL_1434105 (CHEMBL3382783)
IC50
3400±n/a nM
Citation
 Rydzik, AM; Brem, J; Struwe, WB; Kochan, GT; Benesch, JL; Schofield, CJ Ejection of structural zinc leads to inhibition of¿-butyrobetaine hydroxylase. Bioorg Med Chem Lett 24:4954-7 (2014) [PubMed]  Article 
Target
Name:
Gamma-butyrobetaine dioxygenase
Synonyms:
BBH | BBOX | BBOX1 | BODG_HUMAN | Gamma-BBH | Gamma-butyrobetaine hydroxylase | Gamma-butyrobetaine,2-oxoglutarate dioxygenase
Type:
PROTEIN
Mol. Mass.:
44715.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1434107
Residue:
387
Sequence:
MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDVNIGIKGLIFDRKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEGAYADWDVVMSRLRILRQRVENGN
  
Inhibitor
Name:
BDBM50028971
Synonyms:
CHEMBL3335713
Type:
Small organic molecule
Emp. Form.:
C6H5BrSe
Mol. Mass.:
235.97
SMILES:
Br[Se]c1ccccc1
Structure:
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