Reaction Details Report a problem with these data
Target
Group 10 secretory phospholipase A2
Ligand
BDBM50031103
Substrate
n/a
Meas. Tech.
ChEMBL_1442449 (CHEMBL3380079)
IC50
398±n/a nM
Citation
 Chen, H; Knerr, L; Åkerud, T; Hallberg, K; Öster, L; Rohman, M; Österlund, K; Beisel, HG; Olsson, T; Brengdhal, J; Sandmark, J; Bodin, C Discovery of a novel pyrazole series of group X secreted phospholipase A2 inhibitor (sPLA2X) via fragment based virtual screening. Bioorg Med Chem Lett 24:5251-5 (2014) [PubMed]  Article 
Target
Name:
Group 10 secretory phospholipase A2
Synonyms:
Group X secretory phospholipase A2 | PA2GX_HUMAN | PLA2G10
Type:
PROTEIN
Mol. Mass.:
18153.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1442449
Residue:
165
Sequence:
MGPLPVCLPIMLLLLLPSLLLLLLLPGPGSGEASRILRVHRRGILELAGTVGCVGPRTPIAYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGPAENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD
  
Inhibitor
Name:
BDBM50031103
Synonyms:
CHEMBL3337978
Type:
Small organic molecule
Emp. Form.:
C8H5Cl2N3OS
Mol. Mass.:
262.116
SMILES:
NC(=O)c1cc([nH]n1)-c1cc(Cl)sc1Cl
Structure:
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