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Target
Falcipain 2
Ligand
BDBM50033706
Substrate
n/a
Meas. Tech.
ChEMBL_1435072 (CHEMBL3388289)
IC50
>50000±n/a nM
Citation
 Conroy, T; Guo, JT; Elias, N; Cergol, KM; Gut, J; Legac, J; Khatoon, L; Liu, Y; McGowan, S; Rosenthal, PJ; Hunt, NH; Payne, RJ Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. J Med Chem 57:10557-63 (2014) [PubMed]  Article 
Target
Name:
Falcipain 2
Synonyms:
Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2
Type:
Enzyme
Mol. Mass.:
55912.60
Organism:
Plasmodium falciparum
Description:
Recombinant falcipain-2.
Residue:
484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50033706
Synonyms:
CHEMBL3358131
Type:
Small organic molecule
Emp. Form.:
C32H56F3N5O8
Mol. Mass.:
695.8109
SMILES:
[O-]C(=O)C(F)(F)F.CO[C@H]1CC(=O)N([C@H]1C)C(=O)CC[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)[NH+](C)C |r|
Structure:
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