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Target
Cathepsin D
Ligand
BDBM50036571
Substrate
n/a
Meas. Tech.
ChEMBL_1433719 (CHEMBL3386390)
Ki
19300±n/a nM
Citation
Caldwell, JP; Mazzola, RD; Durkin, J; Chen, J; Chen, X; Favreau, L; Kennedy, M; Kuvelkar, R; Lee, J; McHugh, N; McKittrick, B; Orth, P; Stamford, A; Strickland, C; Voigt, J; Wang, L; Zhang, L; Zhang, Q; Zhu, Z Discovery of potent iminoheterocycle BACE1 inhibitors. Bioorg Med Chem Lett 24:5455-9 (2015) [PubMed] Article
More Info.:
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL