Reaction Details Report a problem with these data
Target
Histamine H4 receptor
Ligand
BDBM50036674
Substrate
n/a
Meas. Tech.
ChEMBL_1434446 (CHEMBL3388263)
Ki
2.0±n/a nM
Citation
 Savall, BM; Meduna, SP; Venable, J; Wei, J; Smith, RC; Hack, MD; Thurmond, RL; McGovern, P; Edwards, JP The effect of pK(a) on pyrimidine/pyridine-derived histamine H4 ligands. Bioorg Med Chem Lett 24:5489-92 (2015) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50036674
Synonyms:
CHEMBL3354820
Type:
Small organic molecule
Emp. Form.:
C14H23N5
Mol. Mass.:
261.3659
SMILES:
Nc1cc(cc(NC2CCCC2)n1)N1CCNCC1
Structure:
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