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Target
Protein O-GlcNAcase
Ligand
BDBM50041555
Substrate
n/a
Meas. Tech.
ChEMBL_1445777 (CHEMBL3375486)
EC50
10000±n/a nM
Citation
 Abdel-Magid, AF Inhibition of O-GlcNAcase (OGA): A Potential Therapeutic Target to Treat Alzheimer's Disease. ACS Med Chem Lett 5:1270-1 (2014) [PubMed]  Article 
Target
Name:
Protein O-GlcNAcase
Synonyms:
Beta-N-acetylhexosaminidase | Beta-hexosaminidase | Bifunctional protein NCOAT | Hexc | Hexc | Mea5 | Meningioma-expressed antigen 5 | Mgea5 | N-acetyl-beta-D-glucosaminidase | N-acetyl-beta-glucosaminidase | OGA_RAT | Oga | Protein O-GlcNAcase
Type:
PROTEIN
Mol. Mass.:
102878.65
Organism:
Rattus norvegicus
Description:
ChEMBL_109537
Residue:
916
Sequence:
MVQKESQAALEERESERNANPASVSGASLEPSAAPAPGEDNPSGAGAAAGTGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPSVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKTSVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPSALTKEEEKKQPDEEPMDMVVEKQEESEHKSDNQILTEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCINDIAPMQTDEQANKEQFVPGPNEKPLYAAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCALVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL
  
Inhibitor
Name:
BDBM50041555
Synonyms:
CHEMBL1379586
Type:
Small organic molecule
Emp. Form.:
C17H21N3O2S
Mol. Mass.:
331.433
SMILES:
COC(=O)Nc1ncc(CN2CCC(CC2)c2ccccc2)s1
Structure:
Search PDB for entries with ligand similarity: