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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM50042865
Substrate
n/a
Meas. Tech.
ChEMBL_1444649 (CHEMBL3376647)
IC50
400±n/a nM
Citation
 Ishchenko, A; Zhang, L; Le Brazidec, JY; Fan, J; Chong, JH; Hingway, A; Raditsis, A; Singh, L; Elenbaas, B; Hong, VS; Marcotte, D; Silvian, L; Enyedy, I; Chao, J Structure-based design of low-nanomolar PIM kinase inhibitors. Bioorg Med Chem Lett 25:474-80 (2015) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM50042865
Synonyms:
CHEMBL3354515
Type:
Small organic molecule
Emp. Form.:
C20H17F2N3O3S
Mol. Mass.:
417.429
SMILES:
Fc1cccc(F)c1-c1nc(cs1)C(=O)Nc1cnccc1OC1CCOCC1
Structure:
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