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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM50042870
Substrate
n/a
Meas. Tech.
ChEMBL_1444650 (CHEMBL3376648)
IC50
250±n/a nM
Citation
 Ishchenko, A; Zhang, L; Le Brazidec, JY; Fan, J; Chong, JH; Hingway, A; Raditsis, A; Singh, L; Elenbaas, B; Hong, VS; Marcotte, D; Silvian, L; Enyedy, I; Chao, J Structure-based design of low-nanomolar PIM kinase inhibitors. Bioorg Med Chem Lett 25:474-80 (2015) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50042870
Synonyms:
CHEMBL3354520
Type:
Small organic molecule
Emp. Form.:
C22H22F2N4O
Mol. Mass.:
396.4331
SMILES:
Fc1cccc(F)c1-c1cccc(CNc2cnccc2OC2CCNCC2)n1
Structure:
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