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Target
Serine/threonine-protein kinase Sgk2
Ligand
BDBM50443628
Substrate
n/a
Meas. Tech.
ChEMBL_1445193 (CHEMBL3375445)
IC50
128±n/a nM
Citation
 Halland, N; Schmidt, F; Weiss, T; Saas, J; Li, Z; Czech, J; Dreyer, M; Hofmeister, A; Mertsch, K; Dietz, U; Strübing, C; Nazare, M Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors. ACS Med Chem Lett 6:73-8 (2015) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Sgk2
Synonyms:
SGK2 | SGK2_HUMAN
Type:
PROTEIN
Mol. Mass.:
47609.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1445193
Residue:
427
Sequence:
MQGLLTSGRKPSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPEDDDILDC
  
Inhibitor
Name:
BDBM50443628
Synonyms:
CHEMBL3092468 | US9174993, 35 | US9221828, 35
Type:
Small organic molecule
Emp. Form.:
C17H12ClFN6O2S
Mol. Mass.:
418.833
SMILES:
Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
Structure:
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