Reaction Details Report a problem with these data
Target
Carbonic anhydrase 12
Ligand
BDBM46912
Substrate
n/a
Meas. Tech.
ChEMBL_1447570 (CHEMBL3373765)
IC50
226±n/a nM
Citation
 Rosatelli, E; Carotti, A; Ceruso, M; Supuran, CT; Gioiello, A Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors. Bioorg Med Chem Lett 24:3422-5 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM46912
Synonyms:
4-methyl-N-(2-phenylphenyl)benzenesulfonamide | MLS000575428 | N-2-biphenylyl-4-methylbenzenesulfonamide | SMR000184678 | cid_818647
Type:
Small organic molecule
Emp. Form.:
C19H17NO2S
Mol. Mass.:
323.409
SMILES:
Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: