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Target
Dynamin-2
Ligand
BDBM50055859
Substrate
n/a
Meas. Tech.
ChEMBL_1458574 (CHEMBL3370892)
IC50
23600±n/a nM
Citation
 MacGregor, KA; Abdel-Hamid, MK; Odell, LR; Chau, N; Whiting, A; Robinson, PJ; McCluskey, A Development of quinone analogues as dynamin GTPase inhibitors. Eur J Med Chem 85:191-206 (2014) [PubMed]  Article 
Target
Name:
Dynamin-2
Synonyms:
DYN2_RAT | Dnm2 | Dyn2
Type:
PROTEIN
Mol. Mass.:
98236.76
Organism:
Rattus norvegicus
Description:
ChEMBL_1458574
Residue:
870
Sequence:
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEYAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGRKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPTLRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELISTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESAEQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQNTSSHSPTPQRRPVSSVHPPGRPPAVRGPTPGPPLIPMPVGATSSFSAPPIPSRPGPQNVFANNDPFSAPPQIPSRPARIPPGIPPGVPSRRAPAAPSRPTIIRPAEPSLLD
  
Inhibitor
Name:
BDBM50055859
Synonyms:
CHEMBL3329966
Type:
Small organic molecule
Emp. Form.:
C18H14N2O4
Mol. Mass.:
322.3148
SMILES:
Oc1ccc(NC2=CC(=O)C(Nc3ccc(O)cc3)=CC2=O)cc1 |c:19,t:6|
Structure:
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