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Target
Thromboxane A2 receptor
Ligand
BDBM50058026
Substrate
n/a
Meas. Tech.
ChEMBL_1451468 (CHEMBL3364317)
IC50
54±n/a nM
Citation
 Ballatore, C; Gay, B; Huang, L; Robinson, KH; James, MJ; Trojanowski, JQ; Lee, VM; Brunden, KR; Smith, AB Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group. Bioorg Med Chem Lett 24:4171-5 (2014) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50058026
Synonyms:
CHEMBL3326602
Type:
Small organic molecule
Emp. Form.:
C20H20ClNO4S
Mol. Mass.:
405.895
SMILES:
OC1=C(Cc2cccc(CCNS(=O)(=O)c3ccc(Cl)cc3)c2)CCC1=O |c:1|
Structure:
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