Reaction Details Report a problem with these data
Target
Similar to alpha-tubulin isoform 1
Ligand
BDBM50058381
Substrate
n/a
Meas. Tech.
ChEMBL_1457783 (CHEMBL3369800)
IC50
860±n/a nM
Citation
 Kamal, A; Srinivasa Reddy, T; Polepalli, S; Shalini, N; Reddy, VG; Subba Rao, AV; Jain, N; Shankaraiah, N Synthesis and biological evaluation of podophyllotoxin congeners as tubulin polymerization inhibitors. Bioorg Med Chem 22:5466-75 (2014) [PubMed]  Article 
Target
Name:
Similar to alpha-tubulin isoform 1
Synonyms:
Similar to alpha-tubulin isoform 1
Type:
PROTEIN
Mol. Mass.:
10383.05
Organism:
Bos taurus
Description:
ChEMBL_104716
Residue:
99
Sequence:
CVSASPSTLARLVSRSAMPAGSSTAWNTAFSPMARCQVTKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRSSSTLSSSSQAKKMP
  
Inhibitor
Name:
BDBM50058381
Synonyms:
CHEMBL3334927
Type:
Small organic molecule
Emp. Form.:
C29H25BrN2O7
Mol. Mass.:
593.422
SMILES:
COC(=O)[C@@H]1[C@H](c2cc(OC)c(OC)c(OC)c2)c2cc3OCOc3cc2C=C1c1nc2ccc(Br)cc2[nH]1 |r,c:30|
Structure:
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