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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM50061610
Substrate
n/a
Meas. Tech.
ChEMBL_1461783 (CHEMBL3395659)
IC50
37±n/a nM
Citation
 Wu, B; Wang, HL; Cee, VJ; Lanman, BA; Nixey, T; Pettus, L; Reed, AB; Wurz, RP; Guerrero, N; Sastri, C; Winston, J; Lipford, JR; Lee, MR; Mohr, C; Andrews, KL; Tasker, AS Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors. Bioorg Med Chem Lett 25:775-80 (2015) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM50061610
Synonyms:
CHEMBL3394068 | US9321756, 203
Type:
Small organic molecule
Emp. Form.:
C18H18N6S
Mol. Mass.:
350.441
SMILES:
CC(C)Nc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Structure:
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