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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50063515
Substrate
n/a
Meas. Tech.
ChEMBL_1463343 (CHEMBL3399616)
IC50
726±n/a nM
Citation
 Chirkova, ZV; Kabanova, MV; Filimonov, SI; Abramov, IG; Petzer, A; Petzer, JP; Firgang, SI; Suponitsky, KY Inhibition of monoamine oxidase by indole-5,6-dicarbonitrile derivatives. Bioorg Med Chem Lett 25:1206-11 (2015) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM50063515
Synonyms:
CHEMBL3398526
Type:
Small organic molecule
Emp. Form.:
C17H10BrN3O2
Mol. Mass.:
368.184
SMILES:
COc1ccc(cc1)-c1c(Br)c2cc(C#N)c(cc2n1O)C#N
Structure:
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