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Target
C-X-C chemokine receptor type 2
Ligand
BDBM50065324
Substrate
n/a
Meas. Tech.
ChEMBL_1465563 (CHEMBL3404716)
IC50
5.0±n/a nM
Citation
 Austin, RP; Bennion, C; Bonnert, RV; Cheema, L; Cook, AR; Cox, RJ; Ebden, MR; Gaw, A; Grime, K; Meghani, P; Nicholls, D; Phillips, C; Smith, N; Steele, J; Stonehouse, JP Discovery and evaluation of a novel monocyclic series of CXCR2 antagonists. Bioorg Med Chem Lett 25:1616-20 (2015) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50065324
Synonyms:
CHEMBL3403848
Type:
Small organic molecule
Emp. Form.:
C16H21ClFN5O3S2
Mol. Mass.:
449.951
SMILES:
C[C@H](CO)Nc1cc(NS(=O)(=O)N(C)C)nc(SCc2cccc(Cl)c2F)n1 |r|
Structure:
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