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Target
Carbonic anhydrase 12
Ligand
BDBM50066008
Substrate
n/a
Meas. Tech.
ChEMBL_1464740 (CHEMBL3407091)
Ki
5.5±n/a nM
Citation
 Mojzych, M; Karczmarzyk, Z; Wysocki, W; Ceruso, M; Supuran, CT; Kry?tof, V; Urbanczyk-Lipkowska, Z; Kalicki, P New approaches to the synthesis of sildenafil analogues and their enzyme inhibitory activity. Bioorg Med Chem 23:1421-9 (2015) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50066008
Synonyms:
CHEMBL3401465
Type:
Small organic molecule
Emp. Form.:
C14H16N6O3S
Mol. Mass.:
348.38
SMILES:
CCOc1ccc(cc1-c1nnc2n(C)nc(C)c2n1)S(N)(=O)=O
Structure:
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