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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM52429
Substrate
n/a
Meas. Tech.
ChEMBL_1464331 (CHEMBL3404598)
Ki
4718±n/a nM
Citation
 Smusz, S; Kurczab, R; Satala, G; Bojarski, AJ Fingerprint-based consensus virtual screening towards structurally new 5-HT(6)R ligands. Bioorg Med Chem Lett 25:1827-30 (2015) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM52429
Synonyms:
4-fluoranyl-N-(4-oxidanyl-3-quinolin-8-ylsulfanyl-naphthalen-1-yl)benzenesulfonamide | 4-fluoro-N-(4-hydroxy-3-quinolin-8-ylsulfanylnaphthalen-1-yl)benzenesulfonamide | 4-fluoro-N-[4-hydroxy-3-(8-quinolinylthio)-1-naphthalenyl]benzenesulfonamide | 4-fluoro-N-[4-hydroxy-3-(8-quinolinylthio)-1-naphthyl]benzenesulfonamide | 4-fluoro-N-[4-hydroxy-3-(8-quinolylthio)-1-naphthyl]benzenesulfonamide | MLS000581412 | SMR000200036 | cid_2133793
Type:
Small organic molecule
Emp. Form.:
C25H17FN2O3S2
Mol. Mass.:
476.542
SMILES:
Oc1c(Sc2cccc3cccnc23)cc(NS(=O)(=O)c2ccc(F)cc2)c2ccccc12
Structure:
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