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Target
Ubiquitin carboxyl-terminal hydrolase 10
Ligand
BDBM50069761
Substrate
n/a
Meas. Tech.
ChEMBL_1469497 (CHEMBL3412294)
IC50
600±n/a nM
Citation
 Ndubaku, C; Tsui, V Inhibiting the deubiquitinating enzymes (DUBs). J Med Chem 58:1581-95 (2015) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 10
Synonyms:
Deubiquitinating enzyme 10 | KIAA0190 | UBP10_HUMAN | USP10 | Ubiquitin carboxyl-terminal hydrolase 10 | Ubiquitin thioesterase 10 | Ubiquitin-specific-processing protease 10
Type:
PROTEIN
Mol. Mass.:
87115.60
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109582
Residue:
798
Sequence:
MALHSPQYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQAVDKLPDGQEYQRIEFGVDEVIEPSDTLPRTPSYSISSTLNPQAPEFILGCTASKITPDGITKEASYGSIDCQYPGSALALDGSSNVEAEVLENDGVSGGLGQRERKKKKKRPPGYYSYLKDGGDDSISTEALVNGHANSAVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDSVSDIVPDSPFPGALGSDTRTAGQPEGGPGADFGQSCFPAEAGRDTLSRTAGAQPCVGTDTTENLGVANGQILESSGEGTATNGVELHTTESIDLDPTKPESASPPADGTGSASGTLPVSQPKSWASLFHDSKPSSSSPVAYVETKYSPPAISPLVSEKQVEVKEGLVPVSEDPVAIKIAELLENVTLIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIRPGAAFEPTYIYRLLTVNKSSLSEKGRQEDAEEYLGFILNGLHEEMLNLKKLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDEWEQVGPRNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKESATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELLSPGVKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTDVFQIGLNGWLRIDDQTVKVINQYQVVKPTAERTAYLLYYRRVDLL
  
Inhibitor
Name:
BDBM50069761
Synonyms:
CHEMBL2391504
Type:
Small organic molecule
Emp. Form.:
C15H11F2N3
Mol. Mass.:
271.2647
SMILES:
Fc1ccc(CNc2ncnc3ccc(F)cc23)cc1
Structure:
Search PDB for entries with ligand similarity: