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Target
Protein-arginine deiminase type-4
Ligand
BDBM50071098
Substrate
n/a
Meas. Tech.
ChEMBL_1469305 (CHEMBL3414202)
EC50
20000±n/a nM
Citation
 Subramanian, V; Knight, JS; Parelkar, S; Anguish, L; Coonrod, SA; Kaplan, MJ; Thompson, PR Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors. J Med Chem 58:1337-44 (2015) [PubMed]  Article 
Target
Name:
Protein-arginine deiminase type-4
Synonyms:
PADI4_MOUSE | Pad4 | Pad4 | Padi4 | Pdi4 | Peptidylarginine deiminase IV | Protein-arginine deiminase type IV | Protein-arginine deiminase type-4
Type:
PROTEIN
Mol. Mass.:
74419.41
Organism:
Mus musculus
Description:
ChEMBL_109581
Residue:
666
Sequence:
MAQGAVIHVAPEQPTHAVCVVGTATPLDVRGSAPKGYTTFGITASPGVIVDVIHGPPVKKSTMGASKWPLDPELEVTLQVKAASSRTDDEKVRVSYYGPKTSPVQALIYITGVELSLSADVTRTGRVKPAQAGKDQSTWTWGPGGRGAILLVNCDKEDPQASGMDFEDDKILDNKDLQDMSPMTLSTKTPKDFFEKYQLVLEVPKAKMNRVRVFRATRGKLPSRYKVALGPQQFSYCLELPGGQHSTDFYVEGLAFPDADFKGLIPLTISLLDKSNPELPEALVFQDSVTFRVAPWIMTPNTQPPQEVYVCRVSDNEDFLKSLATLTKKAKCKLTVCPEEENIDDQWMQDEMEIGYIQAPHKTLPVVFDSPRDRGLKDFPVKRVMGPNFGYVTRKLYMSELTGLDAFGNLEVSPPVTVRGKEYPLGRILIGNSGYSSSESRDMHQALQDFLSAQQVQAPVRLFSDWLFVGHVDEFLSFVPARDKQGFRLLLSSPRACYQLFQELQSQGHGEATLFEGLKRKRQTINEILSNKKLRDQNAYVESCIDWNRAVLKRELGLAEGDIIDIPQLFKLAGNSRGNSKAQAFFPNMVNMLVLGKYLGIPKPFGPIIDGHCCLEEEVRSHLEPLGLHCTFINDFYTYHVYNGEVHCGTNVRRKPFTFKWWHMVP
  
Inhibitor
Name:
BDBM50071098
Synonyms:
CHEMBL3409978
Type:
Small organic molecule
Emp. Form.:
C24H30ClN7O
Mol. Mass.:
467.994
SMILES:
CC(C)(C)n1nnc(n1)[C@H](CCCNC(=N)CCl)NC(=O)c1ccc(cc1)-c1ccccc1 |r|
Structure:
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