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Target
4-hydroxyphenylpyruvate dioxygenase
Ligand
BDBM50072263
Substrate
n/a
Meas. Tech.
ChEMBL_1468440 (CHEMBL3412604)
IC50
100±n/a nM
Citation
 Xu, YL; Lin, HY; Ruan, X; Yang, SG; Hao, GF; Yang, WC; Yang, GF Synthesis and bioevaluation of pyrazole-benzimidazolone hybrids as novel human 4-Hydroxyphenylpyruvate dioxygenase inhibitors. Eur J Med Chem 92:427-38 (2015) [PubMed]  Article 
Target
Name:
4-hydroxyphenylpyruvate dioxygenase
Synonyms:
4-hydroxyphenylpyruvate dioxygenase | 4-hydroxyphenylpyruvic acid oxidase | 4HPPD | HPD | HPPD_HUMAN | PPD
Type:
PROTEIN
Mol. Mass.:
44937.33
Organism:
Homo sapiens (Human)
Description:
ChEMBL_123
Residue:
393
Sequence:
MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSREVVSHVIKQGKIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMREPWVEQDKFGKVKFAVLQTYGDTTHTLVEKMNYIGQFLPGYEAPAFMDPLLPKLPKCSLEMIDHIVGNQPDQEMVSASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEVIQRHNHQGFGAGNFNSLFKAFEEEQNLRGNLTNMETNGVVPGM
  
Inhibitor
Name:
BDBM50072263
Synonyms:
CHEMBL3408318
Type:
Small organic molecule
Emp. Form.:
C16H16N4O3
Mol. Mass.:
312.3232
SMILES:
Cn1ncc(C(=O)c2ccc3n(C)c(=O)n(C4CC4)c3c2)c1O
Structure:
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