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Target
Ubl carboxyl-terminal hydrolase 18
Ligand
BDBM50072960
Substrate
n/a
Meas. Tech.
ChEMBL_1467811 (CHEMBL3412536)
IC50
21200±n/a nM
Citation
 Cersosimo, U; Sgorbissa, A; Foti, C; Drioli, S; Angelica, R; Tomasella, A; Picco, R; Semrau, MS; Storici, P; Benedetti, F; Berti, F; Brancolini, C Synthesis, characterization, and optimization for in vivo delivery of a nonselective isopeptidase inhibitor as new antineoplastic agent. J Med Chem 58:1691-704 (2015) [PubMed]  Article 
Target
Name:
Ubl carboxyl-terminal hydrolase 18
Synonyms:
43 kDa ISG15-specific protease | ISG15-specific-processing protease | ISG43 | UBP18_HUMAN | USP18 | Ubl carboxyl-terminal hydrolase 18 | Ubl thioesterase 18 | hUBP43
Type:
PROTEIN
Mol. Mass.:
43018.92
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109576
Residue:
372
Sequence:
MSKAFGLLRQICQSILAESSQSPADLEEKKEEDSNMKREQPRERPRAWDYPHGLVGLHNIGQTCCLNSLIQVFVMNVDFTRILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAVRPLELAYCLQKCNVPLFVQHDAAQLYLKLWNLIKDQITDVHLVERLQALYTIRVKDSLICVDCAMESSRNSSMLTLPLSLFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNICLVSWEDIQCTYGNPNYHWQETAYLLVYMKMEC
  
Inhibitor
Name:
BDBM50072960
Synonyms:
CHEMBL3410537
Type:
Small organic molecule
Emp. Form.:
C20H16N2O6
Mol. Mass.:
380.3508
SMILES:
OC1C\C(=C/c2ccc(cc2)[N+]([O-])=O)C(=O)\C(C1)=C\c1ccc(cc1)[N+]([O-])=O
Structure:
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