Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50135141
Substrate
n/a
Meas. Tech.
ChEMBL_1467842 (CHEMBL3412567)
Ki
24±n/a nM
Citation
 Buron, F; Mérour, JY; Akssira, M; Guillaumet, G; Routier, S Recent advances in the chemistry and biology of pyridopyrimidines. Eur J Med Chem 95:76-95 (2015) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50135141
Synonyms:
6-[(2,5-Dichloro-phenylamino)-methyl]-pyrido[2,3-d]pyrimidine-2,4-diamine | 6-{[(2,5-dichlorophenyl)amino]methyl}pyrido[2,3-d]pyrimidine-2,4-diamine | CHEMBL145979
Type:
Small organic molecule
Emp. Form.:
C14H12Cl2N6
Mol. Mass.:
335.191
SMILES:
Nc1nc(N)c2cc(CNc3cc(Cl)ccc3Cl)cnc2n1
Structure:
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