Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50078753
Substrate
n/a
Meas. Tech.
ChEMBL_1471609 (CHEMBL3420550)
IC50
940±n/a nM
Citation
 Lin, X; Chen, W; Qiu, Z; Guo, L; Zhu, W; Li, W; Wang, Z; Zhang, W; Zhang, Z; Rong, Y; Zhang, M; Yu, L; Zhong, S; Zhao, R; Wu, X; Wong, JC; Tang, G Design and synthesis of orally bioavailable aminopyrrolidinone histone deacetylase 6 inhibitors. J Med Chem 58:2809-20 (2015) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50078753
Synonyms:
CHEMBL3415449
Type:
Small organic molecule
Emp. Form.:
C8H10N2O2
Mol. Mass.:
166.1772
SMILES:
CNc1ccc(cc1)C(=O)NO
Structure:
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