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Target
Heme oxygenase 1
Ligand
BDBM50079992
Substrate
n/a
Meas. Tech.
ChEMBL_1470660 (CHEMBL3420247)
IC50
39800±n/a nM
Citation
 Salerno, L; Pittalą, V; Romeo, G; Modica, MN; Marrazzo, A; Siracusa, MA; Sorrenti, V; Di Giacomo, C; Vanella, L; Parayath, NN; Greish, K Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. Eur J Med Chem 96:162-72 (2015) [PubMed]  Article 
Target
Name:
Heme oxygenase 1
Synonyms:
HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1
Type:
Enzyme
Mol. Mass.:
33005.15
Organism:
Rattus norvegicus (rat)
Description:
HO-1 obtained from rat spleen was used in enzyme assays.
Residue:
289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
  
Inhibitor
Name:
BDBM50079992
Synonyms:
CHEMBL3415250
Type:
Small organic molecule
Emp. Form.:
C15H17N3S2
Mol. Mass.:
303.446
SMILES:
C(CCSc1nc2ccccc2s1)CCn1ccnc1
Structure:
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