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Target
Cellular tumor antigen p53
Ligand
BDBM50080457
Substrate
n/a
Meas. Tech.
ChEMBL_1474783 (CHEMBL3424240)
IC50
6200±n/a nM
Citation
 Tatsuda, D; Momose, I; Someno, T; Sawa, R; Kubota, Y; Iijima, M; Kunisada, T; Watanabe, T; Shibasaki, M; Nomoto, A Quinofuracins A-E, produced by the fungus Staphylotrichum boninense PF1444, show p53-dependent growth suppression. J Nat Prod 78:188-95 (2015) [PubMed]  Article 
Target
Name:
Cellular tumor antigen p53
Synonyms:
Antigen NY-CO-13 | CREB-binding protein/p53 | GST-p53 | His6-p53 | P53 | P53_HUMAN | Phosphoprotein p53 | TP53 | Tumor Suppressor p53
Type:
fusion protein
Mol. Mass.:
43654.73
Organism:
Homo sapiens (Human)
Description:
The full-length His6-wt-p53 expressed in E. coli was used in assays.
Residue:
393
Sequence:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
  
Inhibitor
Name:
BDBM50080457
Synonyms:
CHEMBL3422268
Type:
Small organic molecule
Emp. Form.:
C28H32O13
Mol. Mass.:
576.5459
SMILES:
[H][C@@]1(O[C@@H](CCCCC)c2c(O)cc3C(=O)c4cc(O)cc(O)c4C(=O)c3c2O)O[C@@]([H])([C@H](O)CO)[C@H](O)[C@H]1OC(C)=O |r|
Structure:
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