Target
Delta-type opioid receptor
Ligand
BDBM50087825
Substrate
n/a
Meas. Tech.
ChEMBL_1478282 (CHEMBL3428522)
EC50
200±n/a nM
Citation
 Burford, NTLivingston, KECanals, MRyan, MRBudenholzer, LMHan, YShang, YHerbst, JJO'Connell, JBanks, MZhang, LFilizola, MBassoni, DLWehrman, TSChristopoulos, ATraynor, JRGerritz, SWAlt, A Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of thed-opioid receptor. J Med Chem 58:4220-9 (2015) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50087825
Synonyms:
CHEMBL3426790
Type:
Small organic molecule
Emp. Form.:
C31H34O4
Mol. Mass.:
470.5993
SMILES:
Cc1cccc(COc2ccc(cc2)C2C3=C(CC(C)(C)CC3=O)OC3=C2C(=O)CC(C)(C)C3)c1 |c:27,t:16|
Structure:
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