Reaction Details Report a problem with these data
Target
UDP-glucuronosyltransferase 1A8
Ligand
BDBM50044561
Substrate
n/a
Meas. Tech.
ChEMBL_1492337 (CHEMBL3527918)
Ki
3640±n/a nM
Citation
 Uchihashi, S; Fukumoto, H; Onoda, M; Hayakawa, H; Ikushiro, S; Sakaki, T Metabolism of the c-Fos/activator protein-1 inhibitor T-5224 by multiple human UDP-glucuronosyltransferase isoforms. Drug Metab Dispos 39:803-13 (2011) [PubMed]  Article 
Target
Name:
UDP-glucuronosyltransferase 1A8
Synonyms:
GNT1 | GNT1 | UD18_HUMAN | UDP-glucuronosyltransferase 1-8 | UDP-glucuronosyltransferase 1-H | UDP-glucuronosyltransferase 1A8 | UDPGT 1-8 | UGT-1H | UGT1 | UGT1*8 | UGT1-08 | UGT1.8 | UGT1A8 | UGT1H
Type:
PROTEIN
Mol. Mass.:
59751.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104086
Residue:
530
Sequence:
MARTGWTSPIPLCVSLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLFFSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKYFSLPSVVFARGIACHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
  
Inhibitor
Name:
BDBM50044561
Synonyms:
CHEMBL3222137
Type:
Small organic molecule
Emp. Form.:
C29H27NO8
Mol. Mass.:
517.5266
SMILES:
OC(=O)CCc1cc(ccc1OCc1ccc2c(O)noc2c1)C(=O)c1ccc(OC2CCCC2)cc1O
Structure:
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