Reaction Details
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Report a problem with these dataTarget
Growth hormone secretagogue receptor type 1
Ligand
BDBM50089431
Substrate
n/a
Meas. Tech.
ChEMBL_1496673 (CHEMBL3579244)
EC50
63±n/a nM
Citation
Kilian, TM; Klöting, N; Bergmann, R; Els-Heindl, S; Babilon, S; Clément-Ziza, M; Zhang, Y; Beck-Sickinger, AG; Chollet, C Rational design of dual peptides targeting ghrelin and Y2 receptors to regulate food intake and body weight. J Med Chem 58:4180-93 (2015) [PubMed] Article More Info.:
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
Inhibitor
Name:
BDBM50089431
Synonyms:
CHEMBL3578009
Type:
Small organic molecule
Emp. Form.:
C61H83N11O10
Mol. Mass.:
1130.3794
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(O)=O)C(N)=O |r|
Structure:
