Reaction Details Report a problem with these data
Target
TNF receptor-associated factor 6
Ligand
BDBM50095637
Substrate
n/a
Meas. Tech.
ChEMBL_1502185 (CHEMBL3590970)
Kd
1700000±n/a nM
Citation
 Moriya, J; Takeuchi, K; Tai, K; Arai, K; Kobayashi, N; Yoneda, N; Fukunishi, Y; Inoue, A; Kihara, M; Murakami, T; Chiba, K; Shimada, I Structure-Based Development of a Protein-Protein Interaction Inhibitor Targeting Tumor Necrosis Factor Receptor-Associated Factor 6. J Med Chem 58:5674-83 (2015) [PubMed]  Article 
Target
Name:
TNF receptor-associated factor 6
Synonyms:
6.3.2.- | E3 ubiquitin-protein ligase TRAF6 | Interleukin-1 signal transducer | RING finger protein 85 | RNF85 | TNF receptor-associated factor 6 | TRAF6 | TRAF6_HUMAN
Type:
PROTEIN
Mol. Mass.:
59571.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109817
Residue:
522
Sequence:
MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
  
Inhibitor
Name:
BDBM50095637
Synonyms:
CHEMBL3590512
Type:
Small organic molecule
Emp. Form.:
C16H11ClN2O4S
Mol. Mass.:
362.788
SMILES:
OC(=O)c1ccc(NC(=O)Cn2c3cc(Cl)ccc3sc2=O)cc1
Structure:
Search PDB for entries with ligand similarity: