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Target
Aurora kinase A
Ligand
BDBM50097418
Substrate
n/a
Meas. Tech.
ChEMBL_1502089 (CHEMBL3586964)
IC50
1700±n/a nM
Citation
 Sells, TB; Chau, R; Ecsedy, JA; Gershman, RE; Hoar, K; Huck, J; Janowick, DA; Kadambi, VJ; LeRoy, PJ; Stirling, M; Stroud, SG; Vos, TJ; Weatherhead, GS; Wysong, DR; Zhang, M; Balani, SK; Bolen, JB; Manfredi, MG; Claiborne, CF MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors. ACS Med Chem Lett 6:630-4 (2015) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AURKA_MOUSE | Aik | Airk1 | Ark1 | Aura | Aurka | Aurora Kinase A (Aurora-A) | Aurora kinase A | Aurora-family kinase 1 | Aurora/IPL1-related kinase 1 | Ayk1 | Btak | Iak1 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase Aurora-A | Serine/threonine-protein kinase Ayk1 | Stk15 | Stk6
Type:
Enzyme
Mol. Mass.:
44791.66
Organism:
Mus musculus (mouse)
Description:
n/a
Residue:
395
Sequence:
MDRCKENCVSRPVKTTVPFGPKRVLVTEQIPSQNLGSASSGQAQRVLCPSNSQRVPSQAQKLGAGQKPAPKQLPAASVPRPVSRLNNPQKNEQPAASGNDSEKEQASLQKTEDTKKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKANVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTMCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNASQRLTLAEVLEHPWIKANSSKPPTGHTSKEPTSKSS
  
Inhibitor
Name:
BDBM50097418
Synonyms:
CHEMBL41816
Type:
Small organic molecule
Emp. Form.:
C18H12ClFN4
Mol. Mass.:
338.766
SMILES:
Nc1ncc2CN=C(c3ccccc3F)c3cc(Cl)ccc3-c2n1 |t:6|
Structure:
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