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Target
Histone chaperone ASF1A
Ligand
BDBM50101686
Substrate
n/a
Meas. Tech.
ChEMBL_1462421 (CHEMBL3395843)
IC50
25000±n/a nM
Citation
 Miknis, GF; Stevens, SJ; Smith, LE; Ostrov, DA; Churchill, ME Development of novel Asf1-H3/H4 inhibitors. Bioorg Med Chem Lett 25:963-8 (2015) [PubMed]  Article 
Target
Name:
Histone chaperone ASF1A
Synonyms:
ASF1A | ASF1A_HUMAN | Anti-silencing function protein 1 homolog A | CCG1-interacting factor A | CIA | HSPC146 | Histone chaperone ASF1A | hAsf1 | hAsf1a | hCIA
Type:
PROTEIN
Mol. Mass.:
22950.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109562
Residue:
204
Sequence:
MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLQSLLSTDALPSASKGWSTSENSLNVMLESHMDCM
  
Inhibitor
Name:
BDBM50101686
Synonyms:
CHEMBL3394912
Type:
Small organic molecule
Emp. Form.:
C27H21N3O3
Mol. Mass.:
435.4739
SMILES:
O=C(N\N=C\c1cccc(Oc2ccccc2)c1)c1ccc(NC(=O)c2ccccc2)cc1
Structure:
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