Reaction Details Report a problem with these data
Target
Histamine H4 receptor
Ligand
BDBM50006789
Substrate
n/a
Meas. Tech.
ChEMBL_1521725 (CHEMBL3626548)
Ki
5.3±n/a nM
Citation
 Tichenor, MS; Thurmond, RL; Venable, JD; Savall, BM Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators. J Med Chem 58:7119-27 (2015) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
HH4R | HRH4_MOUSE | Hrh4
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44272.75
Organism:
Mus musculus (mouse)
Description:
Cell pellets from SK-N-MC cells transfected with mouse H4 receptor were used in binding assay.
Residue:
391
Sequence:
MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS
  
Inhibitor
Name:
BDBM50006789
Synonyms:
CHEMBL3236549
Type:
Small organic molecule
Emp. Form.:
C11H19N5
Mol. Mass.:
221.3021
SMILES:
CC(C)c1cc(nc(N)n1)N1CC[C@@H](N)C1 |r|
Structure:
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