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Target
Flap endonuclease 1
Ligand
BDBM50157832
Substrate
n/a
Meas. Tech.
ChEMBL_1517026 (CHEMBL3619485)
IC50
9.0±n/a nM
Citation
 Chapman, TM; Wallace, C; Gillen, KJ; Bakrania, P; Khurana, P; Coombs, PJ; Fox, S; Bureau, EA; Brownlees, J; Melton, DW; Saxty, B N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett 25:4104-8 (2015) [PubMed]  Article 
Target
Name:
Flap endonuclease 1
Synonyms:
DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1
Type:
PROTEIN
Mol. Mass.:
42602.57
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517026
Residue:
380
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSTKKKAKTGAAGKFKRGK
  
Inhibitor
Name:
BDBM50157832
Synonyms:
3-Hydroxy-4a,7a-dihydro-1H-thieno[2,3-d]pyrimidine-2,4-dione | CHEMBL361350
Type:
Small organic molecule
Emp. Form.:
C6H4N2O3S
Mol. Mass.:
184.173
SMILES:
On1c(=O)[nH]c2sccc2c1=O
Structure:
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