Reaction Details Report a problem with these data
Target
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Ligand
BDBM50123834
Substrate
n/a
Meas. Tech.
ChEMBL_1519474 (CHEMBL3625533)
IC50
6430±n/a nM
Citation
 Kim, YG; Seo, JH; Kwak, JH; Shin, KJ Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent. Bioorg Med Chem Lett 25:4481-6 (2015) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Synonyms:
Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | FABI_STAAR | NADPH-dependent enoyl-ACP reductase | fabI | trans-2-enoyl-[acyl carrier protein] reductase
Type:
Enzyme
Mol. Mass.:
27989.00
Organism:
Staphylococcus aureus
Description:
Q6GI75
Residue:
256
Sequence:
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK
  
Inhibitor
Name:
BDBM50123834
Synonyms:
CHEMBL3621749
Type:
Small organic molecule
Emp. Form.:
C21H17Cl2NO3
Mol. Mass.:
402.271
SMILES:
Clc1cccc(Cl)c1Oc1cn(C2CC2)c(COc2ccccc2)cc1=O
Structure:
Search PDB for entries with ligand similarity: