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Target
Growth factor receptor-bound protein 10
Ligand
BDBM50124406
Substrate
n/a
Meas. Tech.
ChEMBL_1520495 (CHEMBL3624734)
Kd
420000±n/a nM
Citation
 Watson, GM; Gunzburg, MJ; Ambaye, ND; Lucas, WA; Traore, DA; Kulkarni, K; Cergol, KM; Payne, RJ; Panjikar, S; Pero, SC; Perlmutter, P; Wilce, MC; Wilce, JA Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J Med Chem 58:7707-18 (2015) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 10
Synonyms:
GRB10 | GRB10 adapter protein | GRB10_HUMAN | GRBIR | GRBIR | Growth factor receptor-bound protein 10 | Insulin receptor-binding protein Grb-IR | KIAA0207
Type:
PROTEIN
Mol. Mass.:
67245.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109892
Residue:
594
Sequence:
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
  
Inhibitor
Name:
BDBM50124406
Synonyms:
CHEMBL3623450
Type:
Small organic molecule
Emp. Form.:
C68H80N14O20S
Mol. Mass.:
1445.51
SMILES:
[H][C@@]12CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@]([H])(NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(cc1)C(O)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc3ccccc3[nH]1)NC(=O)CSC[C@H](NC2=O)C(N)=O)[C@@H](C)O |r|
Structure:
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