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Target
Coagulation factor X
Ligand
BDBM50125980
Substrate
n/a
Meas. Tech.
ChEMBL_1522951 (CHEMBL3630983)
Ki
>28890±n/a nM
Citation
 Zhang, T; Andre, P; Bateman, TJ; Chen, YH; Desai, K; Ellsworth, K; Geissler, WM; Guo, L; Hruza, A; Jian, T; Meng, D; Parker, DL; Qian, X; Reichert, P; Sherer, EC; Shu, M; Smith, CJ; Sonatore, LM; Tschirret-Guth, R; Nolting, AF; Orr, R; Campeau, LC; Araki, K; Nishimura, T; Sakurada, I; Wood, HB Development of a novel class of potent and selective FIXa inhibitors. Bioorg Med Chem Lett 25:4945-9 (2015) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50125980
Synonyms:
CHEMBL3627900
Type:
Small organic molecule
Emp. Form.:
C28H21Cl2F2N5O2
Mol. Mass.:
568.401
SMILES:
Cc1ncn(n1)-c1cc(Cl)c(C(=O)NC[C@@H](c2cccc(F)c2)c2cc(=O)c3c(C)ccc(F)c3[nH]2)c(Cl)c1 |r|
Structure:
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