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Target
Renin
Ligand
BDBM50131684
Substrate
n/a
Meas. Tech.
ChEMBL_1525651 (CHEMBL3637515)
IC50
5.2±n/a nM
Citation
 Sun, X; Wen, X; Chen, YY; Shi, C; Gao, C; Wu, Y; Wang, LJ; Yang, XH; Sun, H Discovery of highly potent renin inhibitors potentially interacting with the S3' subsite of renin. Eur J Med Chem 103:269-88 (2015) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50131684
Synonyms:
CHEMBL3633137
Type:
Small organic molecule
Emp. Form.:
C37H64ClN5O6
Mol. Mass.:
710.387
SMILES:
Cl.COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)Cn2cc(nn2)C2(O)CCCC2)C(C)C)ccc1OC |r|
Structure:
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