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Target
Similar to alpha-tubulin isoform 1
Ligand
BDBM50145077
Substrate
n/a
Meas. Tech.
ChEMBL_1553091 (CHEMBL3766609)
IC50
250±n/a nM
Citation
 Medellin, DC; Zhou, Q; Scott, R; Hill, RM; Frail, SK; Dasari, R; Ontiveros, SJ; Pelly, SC; van Otterlo, WA; Betancourt, T; Shuster, CB; Hamel, E; Bai, R; LaBarbera, DV; Rogelj, S; Frolova, LV; Kornienko, A Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities. J Med Chem 59:480-5 (2016) [PubMed]  Article 
Target
Name:
Similar to alpha-tubulin isoform 1
Synonyms:
Similar to alpha-tubulin isoform 1
Type:
PROTEIN
Mol. Mass.:
10383.05
Organism:
Bos taurus
Description:
ChEMBL_104716
Residue:
99
Sequence:
CVSASPSTLARLVSRSAMPAGSSTAWNTAFSPMARCQVTKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRSSSTLSSSSQAKKMP
  
Inhibitor
Name:
BDBM50145077
Synonyms:
CHEMBL3764535
Type:
Small organic molecule
Emp. Form.:
C24H19N3O2
Mol. Mass.:
381.4266
SMILES:
O=C(c1[nH]c2[nH]c(CCCC#C)nc(=O)c2c1-c1ccccc1)c1ccccc1
Structure:
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