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Target
Cathepsin B
Ligand
BDBM50147767
Substrate
n/a
Meas. Tech.
ChEMBL_1556059 (CHEMBL3768120)
IC50
500000±n/a nM
Citation
 Konno, H; Wakabayashi, M; Takanuma, D; Saito, Y; Akaji, K Design and synthesis of a series of serine derivatives as small molecule inhibitors of the SARS coronavirus 3CL protease. Bioorg Med Chem 24:1241-54 (2016) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
BCSB | CATB_BOVIN | CTSB | Cathepsin B precursor | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
36657.87
Organism:
Bos taurus (bovine)
Description:
Bovine spleen CB was purchased from Sigma Co. (USA).
Residue:
335
Sequence:
MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGMPCTHQY
  
Inhibitor
Name:
BDBM50147767
Synonyms:
CHEMBL3765089
Type:
Small organic molecule
Emp. Form.:
C28H34N2O7
Mol. Mass.:
510.5788
SMILES:
COc1cc(\C=C\C(=O)N[C@H](COC(=O)c2ccccc2)C(=O)NC2CCCCC2)cc(OC)c1OC |r|
Structure:
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