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Target
Solute carrier family 13 member 3
Ligand
BDBM50149244
Substrate
n/a
Meas. Tech.
ChEMBL_1557735 (CHEMBL3773094)
IC50
14100±n/a nM
Citation
 Huard, K; Gosset, JR; Montgomery, JI; Gilbert, A; Hayward, MM; Magee, TV; Cabral, S; Uccello, DP; Bahnck, K; Brown, J; Purkal, J; Gorgoglione, M; Lanba, A; Futatsugi, K; Herr, M; Genung, NE; Aspnes, G; Polivkova, J; Garcia-Irizarry, CN; Li, Q; Canterbury, D; Niosi, M; Vera, NB; Li, Z; Khunte, B; Siderewicz, J; Rolph, T; Erion, DM Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family. J Med Chem 59:1165-75 (2016) [PubMed]  Article 
Target
Name:
Solute carrier family 13 member 3
Synonyms:
NADC3 | NADC3 | Na(+)/dicarboxylate cotransporter 3 | NaDC-3 | S13A3_HUMAN | SDCT2 | SLC13A3 | Sodium-dependent high-affinity dicarboxylate transporter 2 | Solute carrier family 13 member 3 | hNaDC3
Type:
PROTEIN
Mol. Mass.:
66847.40
Organism:
Homo sapiens (Human)
Description:
ChEMBL_114908
Residue:
602
Sequence:
MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESEENTAAVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLAGWLWISFLYGGLSFRGWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWASLFNPGFLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETEPLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTALPPTLANDTFRTL
  
Inhibitor
Name:
BDBM50149244
Synonyms:
CHEMBL3771118
Type:
Small organic molecule
Emp. Form.:
C13H17NO6
Mol. Mass.:
283.2772
SMILES:
COc1ncc(C)cc1CC[C@@](O)(CC(O)=O)C(O)=O |r|
Structure:
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