Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50152106
Substrate
n/a
Meas. Tech.
ChEMBL_1565145 (CHEMBL3782503)
Ki
>40000±n/a nM
Citation
 Deiana, V; Gómez-Cañas, M; Pazos, MR; Fernández-Ruiz, J; Asproni, B; Cichero, E; Fossa, P; Muñoz, E; Deligia, F; Murineddu, G; García-Arencibia, M; Pinna, GA Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties. Eur J Med Chem 112:66-80 (2016) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50152106
Synonyms:
CHEMBL3780124
Type:
Small organic molecule
Emp. Form.:
C25H22Cl2N4O
Mol. Mass.:
465.374
SMILES:
Clc1ccc(c(Cl)c1)-n1nc(C(=O)NN2CCCC2)c2ccc3cc(ccc3c12)C1CC1
Structure:
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