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Target
Solute carrier family 2, facilitated glucose transporter member 2
Ligand
BDBM50155753
Substrate
n/a
Meas. Tech.
ChEMBL_1565337 (CHEMBL3782731)
IC50
880±n/a nM
Citation
 Siebeneicher, H; Bauser, M; Buchmann, B; Heisler, I; Müller, T; Neuhaus, R; Rehwinkel, H; Telser, J; Zorn, L Identification of novel GLUT inhibitors. Bioorg Med Chem Lett 26:1732-7 (2016) [PubMed]  Article 
Target
Name:
Solute carrier family 2, facilitated glucose transporter member 2
Synonyms:
GLUT2 | GTR2_HUMAN | SLC2A2
Type:
PROTEIN
Mol. Mass.:
57494.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_599700
Residue:
524
Sequence:
MTEDKVTGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYVINSTDELPTISYSMNPKPTPWAEEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIKAMLVANILSLVGALLMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTFHQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKRLRGYDDVTKDINEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFYYSTSIFQTAGISKPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEIAAEFQKKSGSAHRPKAAVEMKFLGATETV
  
Inhibitor
Name:
BDBM50155753
Synonyms:
CHEMBL3780470
Type:
Small organic molecule
Emp. Form.:
C23H23FN6O2
Mol. Mass.:
434.4661
SMILES:
COc1ccccc1N1CCN(CC1)c1ncnc2n(ncc12)-c1cc(F)ccc1OC
Structure:
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