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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50158091
Substrate
n/a
Meas. Tech.
ChEMBL_1563129 (CHEMBL3783777)
Ki
21000±n/a nM
Citation
 Lanning, ME; Yu, W; Yap, JL; Chauhan, J; Chen, L; Whiting, E; Pidugu, LS; Atkinson, T; Bailey, H; Li, W; Roth, BM; Hynicka, L; Chesko, K; Toth, EA; Shapiro, P; MacKerell, AD; Wilder, PT; Fletcher, S Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoprotein. Eur J Med Chem 113:273-92 (2016) [PubMed]  Article 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50158091
Synonyms:
CHEMBL3780331 | US10858316, Compound 3f
Type:
Small organic molecule
Emp. Form.:
C18H14ClNO5S
Mol. Mass.:
391.825
SMILES:
OC(=O)c1cc(c2ccccc2c1O)S(=O)(=O)NCc1ccc(Cl)cc1
Structure:
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