Reaction Details Report a problem with these data
Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50160699
Substrate
n/a
Meas. Tech.
ChEMBL_1566417 (CHEMBL3790037)
IC50
1500±n/a nM
Citation
 Kajanus, J; Jacobson, I; Åstrand, A; Olsson, RI; Gran, U; Björe, A; Fjellström, O; Davidsson, Ö; Emtenäs, H; Dahlén, A; Löfberg, B; Yuan, ZQ; Sundell, J; Cassel, J; Gyll, J; Iliefski, T; Högberg, Å; Lindhardt, E; Malmberg, J Isoindolinone compounds active as Kv1.5 blockers identified using a multicomponent reaction approach. Bioorg Med Chem Lett 26:2023-9 (2016) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50160699
Synonyms:
CHEMBL3786460
Type:
Small organic molecule
Emp. Form.:
C26H24F2N2O2
Mol. Mass.:
434.4778
SMILES:
CC(C)(C)NC(=O)C1N(Cc2ccccc2-c2ccc(F)c(F)c2)C(=O)c2ccccc12
Structure:
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