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Target
Nuclear receptor ROR-beta
Ligand
BDBM50108881
Substrate
n/a
Meas. Tech.
ChEMBL_1571962 (CHEMBL3796420)
EC50
1100±n/a nM
Citation
 Enyedy, IJ; Powell, NA; Caravella, J; van Vloten, K; Chao, J; Banerjee, D; Marcotte, D; Silvian, L; McKenzie, A; Hong, VS; Fontenot, JD Discovery of biaryls as ROR¿ inverse agonists by using structure-based design. Bioorg Med Chem Lett 26:2459-63 (2016) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-beta
Synonyms:
NR1F2 | Nuclear receptor RZR-beta | Nuclear receptor subfamily 1 group F member 2 | RORB | RORB_HUMAN | RZRB | Retinoid-related orphan receptor-beta
Type:
PROTEIN
Mol. Mass.:
53227.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107979
Residue:
470
Sequence:
MCENQLKTKADATAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
  
Inhibitor
Name:
BDBM50108881
Synonyms:
CHEMBL3596591
Type:
Small organic molecule
Emp. Form.:
C23H17Cl2FN2O2
Mol. Mass.:
443.298
SMILES:
NC(=O)c1ccc(Cl)c(c1)-c1ccc2N(CCCc2c1)C(=O)c1c(F)cccc1Cl
Structure:
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